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Sunday, May 10, 2020 | History

2 edition of Thrombospondin gene family found in the catalog.

Thrombospondin gene family

Josephine C. Adams

Thrombospondin gene family

by Josephine C. Adams

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Published by Springer, Landes in New York, London, Austin, TX .
Written in English


Edition Notes

StatementJosephine C. Adams,Richard P. Tucker, Jack Lawler.
SeriesMolecular biology intelligence unit
ContributionsTucker, Richard Paul., Lawler, Jack.
The Physical Object
Pagination191p. ;
Number of Pages191
ID Numbers
Open LibraryOL22806100M
ISBN 103540603999

TSP2 is a member of the thrombospondin family that also contains thrombospondin-1, thrombospondin-3, thrombospondin-4, and cartilage oligomeric matrix protein (COMP). The central type 1 repeats are also known as thrombospondin-repeats and are shared with the larger thrombospondin/properdin repeat superfamily.   The only other members of the thrombospondin gene family that have an RGD sequence in this position are human and bovine COMP (Morgelin et al. ; Newton et al., ). However, the RGD sequence that is present in all of the thrombospondin-1 and −2 proteins is in an equivalent position in the seventh type 3 repeat (Lawler et al., b).

  Thrombospondin 2 expression is correlated with inhibition of angiogenesis and metastasis of colon cancer 4, a new member of the thrombospondin gene family Cited by: Thrombospondin is a protein from platelet a-granules. It is made up of three identical subunits bound by interchain disulfides. It is secreted at sites of platelet activation and aggregation and is involved in the processes of chemotaxis, adhesion, proliferation and differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells.

local gene-delivery systems that inhibit neovasculariza-tion, have shown their beneficial effects in preventing or treating experimental arthritis (2). Thrombospondin 1 (TSP-1) is an endogenous inhibitor of angiogenesis and tumor growth (3). More-over, TSP-1 converts transforming growth factor (TGF) from its latent form to its active form, and Cited by: Thrombospondin-1 (TSP-1) is a member of the synaptogenesis at late recovery phase (3 weeks) are thrombospondin family, an extracellular matrix protein secreted mainly by astrocytes in the brain [1]. It has been known that TSP-1 mediates cellcell and - cell-matrix interactions through communicating with membrane receptors, other extracellular matrixFile Size: 1MB.


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Thrombospondin gene family by Josephine C. Adams Download PDF EPUB FB2

This text describes the functional properties and the structural organization of the members of the thrombospondin gene family. These proteins comprise a family of extracellular calcium binding proteins that modulate cellular adhesion, migration and proliferation.

The prototypic member of the family is thrombospondin-1 (TSP-1), which has functions in platelet aggregation, inflammatory response and the regulation of angiogenesis during wound repair and. The five members of the thrombospondin family are designated thrombospondin-1 to thrombospondin-5 [].

Thrombospondin-5 is also known as cartilage oligomeric matrix protein (COMP). The thrombospondins are multimeric, multidomain glycoproteins that function at cell surfaces and in the extracellular matrix.

Thrombospondin-1 (TSP1) was first characterized in by Baenziger et al. as a glycoprotein released from the α-granules of platelets in response to treatment with thrombin (Roberts and Lau ).This large protein consists of three kDa disulfide-linked subunits and is highly conserved among vertebrate species (Carlson et al.

is a platform for academics to share research papers. Identification and Characterization of Thrombospondin-4, a New Member of the Thrombospondin Gene Family Jack Lawler,* Mark Duquette,* Charles A.

Identification and characterization of thrombospondin-4, a new member of the thrombospondin gene family. The thrombospondins (TSPs) comprise a family of glycosylated, extracellular matrix proteins with well-characterized roles in cell–cell and cell–matrix interactions.

To date, five members have been described TSP-1 to TSP Of this family, TSP-1 and TSP-2 have anti-angiogenic properties. The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions.

TSP3 has been found to be involved in the regulation of skeletal maturation. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Aliases: THBS3, TSP3, thrombospondin 3.

Thrombospondin 1 (TSP-1) is encoded by was first isolated from platelets that had been stimulated with thrombin, and so was designated 'thrombin-sensitive protein'. Since its first recognition, functions for TSP-1 have been found in multiple biological processes including angiogenesis, apoptosis, activation of TGF-beta and Immune regulation.

As such, TSP-1 is designated a InterPro: IPR Vos HL, Devarayalu S, de Vries Y, Bornstein P. Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family. J Biol Chem ;, Google Scholar. A new member of the thrombospondin gene family, designated thrombospondin-4, has been identified in the Xenopus laevis genome.

The predicted amino acid sequence indicates that the protein is similar to the other members of this gene family in the structure of the type 3 repeats and the COOH-terminal domain. Induction of thrombospondin 1 (TSP-1) is generally assumed to suppress tumor growth through inhibiting angiogenesis; however, it is less clear how TSP-1 in dendritic cells (DCs) influences tumor progression.

We investigated tumor growth and immune mechanism by downregulation of TSP-1 in dendritic cells. Administration of TSP-1 small hairpin RNA (shRNA) through the skin produced Cited by: ADS Classic is now deprecated. It will be completely retired in October Please redirect your searches to the new ADS modern form or the classic info can be found on our blog.

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I know that The Family Tree Guide to DNA Testing and Genetic Genealogy will be one of those titles for /5(). THBS1 is a member of the thrombospondin family that also contains THBS2, THBS3, THBS4, and COMP (cartilage oligomeric matrix protein) which arose from gene duplication of a single primordial thrombospondin in insects (Adams and Lawler, ).

The central type 1 repeats are also known as thrombospondin-repeats (TSRs) and are shared with the. The TSPs and Their Expression. The vertebrate thrombospondin family has 5 members. Each is a product of a distinct gene, and the 3 myocardial infarction-associated members, TSP-1, TSP-2, and TSP-4, reside on different chromosomes (15, 6, and 5, respectively).Cited by: Structural Organization of the Thrombospondin Molecule.

in Seminars in Thrombosis and Hemostasis. (Thieme Medical Publishers, Inc. New York, NY). Lawler, J. and Hynes, R.O. The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins.

A more likely ligand would be a member of the thrombospondin gene family, as these extracellular matrix molecules are expressed in N.

Integrins of the starlet sea anemone Nematostella vectensis Patients with type II diabetes have increased populations of platelets that express activation-dependent adhesion molecules, such as activated GpIIb-IIIa, lysosomal Gp53, thrombospondin, and Pselectin.

Prophylactic effects of thrombospondin 1 (TSP‐1) gene transfer on rat collagen‐induced arthritis. Groups of 10 rats were immunized with collagen on days 0 and 7 followed by intraarticular injection of adenoviral vectors AdTSP‐1 or AdLacZ (5 × 10 7 plaque‐forming units) into the ankle joints on days 7 and The AdTSP‐1–treated rats showed a reduction in arthritis on both hind Cited by: The world's first wiki where authorship really matters.

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